Philadelphia chromosome or Philadelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML). It is the result of a reciprocal translocation between chromosome 9 and 22, and is specifically designated t(9;22)(q34;q11). The presence of this translocation is a highly sensitive test for CML, s...
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http://en.wikipedia.org/wiki/Philadelphia_chromosome
(from the article `blood disease`) ...thus giving rise to a clone of leukemic cells. In many cases of leukemia, the mutation is detectable by analysis of the chromosomes of leukemic ... ...is joined to another chromosome. As a result of such an event, two separate genes can be fused. In some cases the newly created gene leads to ... ...
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http://www.britannica.com/eb/a-z/p/55
An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it. Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia.
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http://www.cancer.gov/dictionary?expand=P
<genetics, oncology> Characteristic chromosomal abnormality in which a portion of chromosome 22 is translocated to chromosome 9. This abnormality is found in nearly all cases of chronic myeloid leukaemia and some cases of acute lymphoblastic leukaemia. ... (30 Sep 1997) ...
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http://www.encyclo.co.uk/local/20973
an abnormality of chromosome 22, characterized by shortening of its long arms (the missing portion usually translocated to chromosome 9) and present in marrow cells of most patients with chronic granulocytic leukemia.
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http://www.encyclo.co.uk/local/21001
Characteristic chromosomal abnormality of chronic myelogenous leukaemia in which a portion of chromosome 22 is translocated to chromosome 9.
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http://www.encyclo.co.uk/visitor-contributions.php
(Ph1) Type: Term Definitions: 1. an abnormally shortened chromosome 22, formed by translocation of a portion of the long arm of chromosome 22 to chromosome 9; found in cultured leukocytes of many patients with chronic granulocytic leukemia.
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http://www.medilexicon.com/medicaldictionary.php?t=17493
A genetic abnormality found in some types of leukaemia. Some of the DNA from one chromosome (no. 9) moves over to another chromosome (no. 22). This type of genetic fault is called a translocation.
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https://www.encyclo.co.uk/local/20753
No exact match found.
